DIPHYLLOBOTHRIUM LATUM FAQS

Frequently Asked Questions (FAQs)
Biology
Resouces for Health Professionals

Diphyllobothrium latum and related species (the fish or broad tapeworm), the largest tapeworms that can infect people, can grow up to 30 feet long. While most infections are asymptomatic, complications include intestinal obstruction and gall bladder disease caused by migration of proglottids. Diagnosis is made by identification of eggs or segments of the tapeworm in a stool sample with a microscope. Safe and effective medications are available to treat Diphyllobothrium. Infections are acquired by eating raw or undercooked fish, usually from the Northern Hemisphere (Europe, newly independent states of the Former Soviet Union, North America, Asia), but cases have also been reported in Uganda and Chile. Fish infected with Diphyllobothrium larvae may be transported to and consumed in any area of the world. Adequately freezing or cooking fish will kill the parasite.

BIOLOGY

Causal Agent
The cestode Diphyllobothrium latum (the fish or broad tapeworm), the largest human tapeworm. Several other Diphyllobothrium species have been reported to infect humans, but less frequently; they include D. pacificum, D. cordatum, D. ursi, D. dendriticum, D. lanceolatum, D. dalliae, and D. yonagoensis.

Life Cycle:

Immature eggs are passed in feces. Under appropriate conditions, the eggs mature (approximately 18 to 20 days) and yield oncospheres which develop into a coracidia. After ingestion by a suitable freshwater crustacean (the copepod first intermediate host) the coracidia develop into procercoid larvae. Following ingestion of the copepod by a suitable second intermediate host, typically minnows and other small freshwater fish, the procercoid larvae are released from the crustacean and migrate into the fish flesh where they develop into a plerocercoid larvae (sparganum). The plerocercoid larvae are the infective stage for humans. Because humans do not generally eat undercooked minnows and similar small freshwater fish, these do not represent an important source of infection.

Nevertheless, these small second intermediate hosts can be eaten by larger predator species, e.g., trout, perch, walleyed pike. In this case, the sparganum can migrate to the musculature of the larger predator fish and humans can acquire the disease by eating these later intermediate infected host fish raw or undercooked. After ingestion of the infected fish, the plerocercoid develop into immature adults and then into mature adult tapeworms which will reside in the small intestine. The adults of D. latum attach to the intestinal mucosa by means of the two bilateral groves (bothria) of their scolex. The adults can reach more than 10 m in length, with more than 3,000 proglottids. Immature eggs are discharged from the proglottids (up to 1,000,000 eggs per day per worm) and are passed in the feces. Eggs appear in the feces 5 to 6 weeks after infection. In addition to humans, many other mammals can also serve as definitive hosts for D. latum.

Life cycle image and information courtesy of DPDx.

For more information view the source: Center for Disease Control

Recommended Test: Full GI Panel

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